Characterization of novel E1 and E2 enzymes and their role in ubiquitin and FAT10 conjugation
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چکیده
Acknowledgements Acknowledgements 2 First of all I would like to thank Prof. Marcus Groettrup for giving me the opportunity to perform my PhD in his group. Thank you for supplying optimal working conditions and providing scientific guidance over the past years. Thank you to Prof. Martin Scheffner's group for the collaboration in the UBE1L2 paper and for lots of advice. I would like to express my gratitude to Dr. Gunter Schmidtke, who helped me a lot with biochemical problems and didn't get tired of explaining things to me. Thank you for providing useful technical tips and tricks. Special thanks go to Ingrid Kassner who made my PhD years more fun. It was great to have you as a " Vertiefungskurs " student, a diploma student and as a " HiWi ". I also had a privilege to work with very nice and skilled people in the FAT10 lab. My thanks go to my fellow PhD students Birte, Sebastian and Neha. Further thanks go to Elisabeth and Tina who technically supported us in the lab. I very much appreciate the collaboration with Annette Aichem at the BITg. Thank you for giving me the opportunity to participate at the E2 story. Thank you also to the rest of the immunology lab members for the great atmosphere in our Furthermore, I would like to thank Carolina and Jacky who became good friends over the last years. Thank you for your support. Finally, special thanks go to my family and all my friends, who constantly supported me during my PhD. Thank you for always being there for me.
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Conjugation of the Ubiquitin Activating Enzyme UBE1 with the Ubiquitin-Like Modifier FAT10 Targets It for Proteasomal Degradation
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